palmitoyl pentapeptide-4 (Matrixyl)

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A signal peptide and fragment of procollagen type 1, palmitoyl pentapeptide-4 (previously referred to as palmitoyl pentapeptide-3) is sold commercially as Matrixyl. Palmitic acid is added to the peptide chain to improve penetration. Hailed as a very promising cosmeceutical ingredient during the 20th World Congress of Dermatology in Paris, 2002, research showed palmitoyl pentapeptide-4 produced substantial improvements in wrinkle appearance more quickly than retinol and without the negative effects such as irritation and dryness.

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